报告名称：小鼠基因组的实践操作和小鼠胚胎学的相关技术

报告人：Richard S. Nowakowski  教授

时  间：2014年3月18日（周二）下午2:30

地  点：交大医学部护理楼多功能厅

 

医学部科学技术与学科建设处、人才培养处、人力资源处

2014年3月17日

 

 

   佛罗里达州立大学医学院生物医学系主任，发育神经生物学家。毕业于威斯康星大学，哈佛大学博士，杜克大学博士后。任Cerebral Cortex、Journal of Comparative Neurology、Journal of Neuroscience、Developmental Neuroscience等多种神经科学领域著名杂志副主编或者编委。他的主要研究领域是大脑皮层的发育，特别是细胞增殖和迁移的调控，以及神经元数量的调控。他的著作大部分与干细胞和祖细胞的行为相关，他最出名的成就是引入溴脱氧尿苷（BrdU）法研究大脑中的细胞增殖。他的著作还包括了将动物研究成果转化到人类脑发育的概念中。他近期的研究工作集中在大脑和神经再生过程中个体差异的遗传学研究。

 

Mary Shine Peterson Undergraduate Scholarship in Biochemistry

Phi Beta Kappa, Sigma Xi

Woodrow Wilson Fellowship, 1971-1972

National Science Foundation (Predoctoral) Fellowship, 1972-1975

NIH Postdoctoral Fellowship, 1976-1979

NIH Research Career Development Award, 1986

Academia Rodinensis pro Remediatione (an international society devoted to research and remediation of dyslexia -- named after the father of the sculptor Rodin), elected member 1984-

Excellence in Teaching Award from Foundation of the University of Medicine and Dentistry of New Jersey (1993-1994 academic year)

Raviola Memorial Lecture, Boston University (2003)

New Jersey Professor of Spinal Cord Research (Named Chair Award from the New Jersey Commission on Spinal Cord Research, 2004-2009)

Visiting Professor (2008-present, University of Belgrade (Serbia). I have been chosen by the Faculty of Medicine to serve as a Visiting Professor. I visit and give a series of lectures on my research and I serve as a consultant to  various faculty research efforts.

UMDNJ-Credo Award (2011). This is the highest award from the university. It was given to me for my roles and activities as a mentor for junior faculty and postdocs.

 

1.      Rakic, P. and R.S. Nowakowski. The time of origin of neurons in the hippocampal region of the rhesus monkey. J.Comp Neurol. 196: 99-128, 1981.

2.      Nowakowski, R.S., S.B. Lewin, and M.W. Miller. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J.Neurocytol. 18: 311-318, 1989.

3.      Takahashi, T., R.S. Nowakowski, and V. S. Caviness, Jr. Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse. J.Neurosci. 13: 820-833, 1993.

4.      Takahashi, T., R.S. Nowakowski, and V. S. Caviness, Jr. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J.Neurosci. 16: 6183-6196, 1996.

5.      Cai, L., N. L. Hayes, and R.S. Nowakowski. Local homogeneity of cell cycle length in developing mouse cortex. J.Neurosci. 17: 2079-2087, 1997.

6.      Cai, L., N. L. Hayes, and R.S. Nowakowski. Synchrony of clonal cell proliferation and contiguity of clonally related cells: production of mosaicism in the ventricular zone of developing mouse neocortex. J.Neurosci. 17: 2088-2100, 1997.

7.      Takahashi, T., R.S. Nowakowski, and V. S. Caviness, Jr. The mathematics of neocortical neuronogenesis. Dev.Neurosci. 19: 17-22, 1997.

8.      Hayes, N. L. and R.S. Nowakowski. Exploiting the dynamics of S-phase tracers in developing brain: interkinetic nuclear migration for cells entering versus leaving the S- phase. Dev.Neurosci. 22: 44-55, 2000.

9.      Gilmore, E., R.S. Nowakowski, V.S. Caviness, Jr. and K. Herrup (2000) Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together? Trends in Neuroscience 23: 100-105.

10.  Nowakowski R.S. and Hayes N.L. (2000) New Neurons: Extraordinary Evidence or Extraordinary Conclusion? Science 288:771a-773a.

11.  Caviness, V.S., Jr., T. Takahashi and R.S. Nowakowski (2000) Neuronogenesis and the early events of neocortical histogenesis., In: Development of Cerebral Cortex (Ed. A. Goffinet and P. Rakic). In: Results and Problems in Cell Differentiation. 30: 107-143.

12.  Hayes, NL and RS Nowakowski (2002) Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice. Dev. Brain Research. 134:77-85.

13.  Rachel, RA, G. Dölen, NL Hayes, A. Lu, L Erskine, R.S. Nowakowski, and CA Mason. (2002). Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J. Neuroscience, 22: 4249-4263.

14.  Cai, L., N.L. Hayes, T. Takahashi, V.S. Caviness, Jr. and R.S. Nowakowski (2003). Size Distribution of Retrovirally Marked Lineages Matches Prediction from Population Measurements of Cell Cycle Behavior in Early Developing Mouse Neocortex. J. Neuroscience Research, 69:731-44.

15.  Nowakowski, R.S. and N.L. Hayes, 2007. Cell Cycle and Neurogenesis. In: Adult Neurogenesis (Eds. F.H. Gage, G. Kemperman, and H. Song). Cold Spring Harbor Press, New York, pp. 7-23.

16.  Caviness VS, Bhide PG, Nowakowski R.S., 2008. Histogenetic processes leading to the laminated neocortex: migration is only a part of the story. Dev Neurosci. 30:82-95.

17.  Nowakowski, R.S. and Hayes, N.L., 2008. Radiation, retardation and the developing brain: time is the crucial variable. Acta Paediatrica, 97: 527-531.

18.  Caviness, V.S., P.G. Bhide and R.S. Nowakowski, 2009. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends in Neuroscience, 32:443-450.

19.  Cooper MA, Crockett DP, Nowakowski RS, Gale NW, Zhou R., 2009. Distribution of EphA5 receptor protein in the developing and adult mouse nervous system. J Comp Neurol. 514:310-28.

20.  Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW., 2009 Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 3:55.

21.  Nguyen, T.T., R.S. Nowakowski and I.P. Androulakis, 2009. Unsupervised selection of highly coexpressed and noncoexpressed genes using a consensus clustering approach OMICS 13:219-237.

22.  Caviness VS Jr, Nowakowski RS, Bhide PG., 2009. Neocortical neurogenesis: morphogenetic gradients and beyond. Trends Neurosci. 2009 32:443-50.

23.  Poon A, Li Z, Wolfe GW, Lu L, Williams RW, Hayes NL, Nowakowski RS, Goldowitz D., 2010. Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain. Eur J Neurosci. 32:523-37.

24.  Megraw TL, Sharkey JT, and Nowakowski  RS., 2011. Cdk5rap2 exposes the centrosomal root of microcephaly syndromes. Trends Cell Biol. May 31. [Epub ahead of print] PMID: 21632253 [PubMed - as supplied by publisher].

25.  Nowakowski, R.S. and N.L. Hayes, 2012. Overview of Early Brain Development: Linking Genetics to Brain Structure. In: Developmental Dyslexia: Cross-Disciplinary Insights on Early Precursors, Expression, and Remediation. A volume in the Extraordinary Brain Series. (edited by April A. Benasich and R. Holly Fitch) in press.

26.  Kulkarni, V, N.L. Hayes and R.S. Nowakowski, in preparation. Regionalization of the Ventricular Zone by Cell Cycle Dynamics in the Developing Mouse Hippocampus. Submitted to Cerebral Cortex.

27.  Hayes, NL, and RS Nowakowski, in preparation. Genetic controls of Adult Neurogenesis in the mouse. To be submitted to J. Neurosci.